Evaluation of the impact of coronary artery bypass grafting surgery on soluble markers of endothelial activation, vascular and intercellular adhesion molecules
Mindaugas Balčiūnas, Loreta Bagdonaitė, Robertas Samalavičius, Laimonas Griskevičius Seminars in Cardiovascular Medicine 2009; 15: 4
Objectives: Cardiac operations using cardiopulmonary bypass are associated with the release of cytokines, the activation of the coagulation cascade and endothelial cells. We evaluated the impact of coronary artery bypass grafting (CABG) surgery on endothelial activation measuring levels of soluble intercellular and vascular adhesion molecules (sICAM-1 and sVCAM-1). Design and Methods: Sera levels of soluble ICAM-1 and VCAM-1 were measured in blood samples drawn from a peripheral vein in 66 patients on the day of surgery and on the first postoperative day 12 hours after elective on-pump CABG Soluble adhesion molecule levels were measured by standard enzyme linked immuno-sorbent assays (ELISA). Results: Mean sera levels of sVCAM-1 and sICAM-1 increased significantly after surgery compared to the preoperative value (p < 0.001). No correlations were found between postoperative concentrations of adhesion molecules and the duration of the aorta cross clamp, extracorporeal circulation or surgery. Conclusion: The cardiac surgery procedure resulted in the increased sera levels of both soluble ICAM-1 and VCAM-1 adhesion molecules implying the endothelial activation after on-pump coronary artery bypass grafting.
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